Occupational exposure to flour dust and the risk of head and neck cancer
CARTON ; MENVIELLE ; CYR ; SANCHEZ ; PILORGET ; GUIZARD ; STUCKER ; LUCE
Type de document
ARTICLE A COMITE DE LECTURE REPERTORIE DANS BDI (ACL)
Langue
anglais
Auteur
CARTON ; MENVIELLE ; CYR ; SANCHEZ ; PILORGET ; GUIZARD ; STUCKER ; LUCE
Résumé / Abstract
BackgroundTo investigate the association between head and neck squamous cell cancer (HNSCC) risk and occupational exposure to flour dust in women and men, using data from ICARE, a French population-based case-control study. MethodsThe analysis included 2053 cases of HNSCC and 3507 controls. Lifelong occupational history was collected. A job-exposure matrix was used to assess exposure to flour dust. Odds-ratios (ORs) and 95% confidence intervals (CI), adjusted for smoking, alcohol drinking, and asbestos exposure, were estimated with logistic regression models. ResultsEver exposure to flour dust was associated with elevated ORs in women (OR=2.15, 95%CI 1.01 4.55) and in men (OR=1.55, 95%CI 1.11 2.17). In women, the risk increased with the probability, the duration, and the cumulative level of exposure. No dose-response relationships were observed in men. ConclusionsAlthough the results were less conclusive in men than in women, overall, these findings provide some support to the hypothesis of a role of flour dust in the occurrence of HNSCC.
Source
American Journal of Industrial Medicine, num. 10, 869-873 p.
Editeur
Wiley
