Effects of codoliprane and zolpidem, alone or in combination on performance of aging drivers in driving situation
BOCCA ; AMATO ; MARIE ; LELONG-BOULOUARD ; PAILLET-LOILIER ; COQUEREL ; DENISE ; BERTHELON
Type de document
COMMUNICATION ORALE SANS ACTES (COM)
Langue
anglais
Auteur
BOCCA ; AMATO ; MARIE ; LELONG-BOULOUARD ; PAILLET-LOILIER ; COQUEREL ; DENISE ; BERTHELON
Résumé / Abstract
The majority of older adults regularly use several medications, in particular due to an increase of insomnia with age, but also due to an increase of pain. Paradoxically, most of experimental studies on drugs effects are conducted on healthy young subjects. The aim of the present study was to evaluate the effects of the combination of zolpidem 10 mg taken at bedtime and codoliprane taken at awakening (codeine 20 mg - paracetamol 400 mg) in aged subjects. It was a cross-over, double-blind, placebo-controlled study. Four combinations were tested: placebo-placebo, zolpidem-placebo, zolpidem-codoliprane, placebo-codoliprane. Subjects performed three driving test at 9.00 am : monotonous, urban and car following. Sixteen healthy subjects aged 55 to 65 years participated in this experiment. Standart Deviation of Lateral Position (SDLP) was significantly increased both with zolpidem and with codeine-paracetamol alone. The combination of these two drugs are less clear but tendencies were found. Results are not significant with urban driving test. Globally, results confirms that zolpidem or codoliprane in aged subjects impair driving performance, a result no found in young subjects. Although unexpected, the combination of two drugs did not clearly impair the driving behaviour in the highway driving task.
