Platelet aggregation and HDL cholesterol are predictive of acute coronary events in heart transplant recipients
DE LORGERIL ; BOISSONNAT ; MAMELLE ; MARTIN ; MONJAUD ; GUIDOLLET ; DUREAU ; NINET ; RENAUD
Type de document
ARTICLE DE PERIODIQUE
Langue
anglais
Auteur
DE LORGERIL ; BOISSONNAT ; MAMELLE ; MARTIN ; MONJAUD ; GUIDOLLET ; DUREAU ; NINET ; RENAUD
Résumé / Abstract
Background Sudden death (SD) and acute myocardial infarction (AMI) are the main complications limiting long-term survival after heart transplantation (HT). They are unpredictable and, at present, unpreventable. Platelet aggregation (PA) has recently emerged as a significant prognostic indicator in nontransplanted coronary disease patients. The main purpose of the present study was to evaluate to what extent PA could predict SD and AMI in long-term survivors of HT independently of serum lipid levels. Methods and Results We studied 207 patients. All received triple immunosuppressive therapy. During follow-up, the incidence of SD and AMI was determined, and the independent role of PA as predictor was evaluated with other usual risk factors by a Cox multivariate regression model. Mots-clés : Transplantation ; Coeur ; Infarctus ; Myocarde ; Thrombocyte ; Agrégation ; Cholestérol HDL ; Mort subite ; Etude longitudinale ; Complication ; Exploration ; Facteur risque ; Homme ; Chirurgie ; Appareil circulatoire pathologie ; Cardiopathie coronaire ; Myocarde pathologie ; Artère pathologie ; Vaisseau sanguin pathologie.
